An Efficient Asymmetric Cross-Coupling Reaction in Aqueous Media Mediated by Chiral Chelating Mono Phosphane Atropisomeric Biaryl Ligand

The enantiomerically pure ligand BisNap-Phos was obtained in a straightforward sequence of reactions beginning with inexpensive starting materials under the readily affordable conditions high overall yield. An asymmetric BisNap-Phos-palladium complex-catalyzed Suzuki–Miyaura coupling leading to axially chiral biaryl compounds described. were carried out mild aqueous and organic media. A series atropisomeric biaryls synthesized excellent yields enantioselectivities (up 86% ee). methodology provides an efficient practical strategy for synthesis novel multifunctionalized environmentally friendly easily conditions.